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Study Suggests Expansion of Take-Home Methadone Did Not Contribute to Methadone-Involved Overdoses


July 14, 2022

In March of 2020, the Substance Abuse and Mental Health Services Administration (SAMHSA) allowed states to request blanket exceptions to be able to provide up to 28 and 14 days of take-home methadone for stable and less-stable patients, respectively. This move aimed to facilitate access to methadone treatment from opioid treatment programs (OTPs) during the COVID-19 pandemic.

A research letter released today in JAMA Network, Methadone-Involved Overdose Deaths in the US Before and After Federal Policy Changes Expanding Take-Home Methadone Doses From Opioid Treatment Programs, aimed to look at the impact of these changes on methadone-involved overdose deaths.

The study findings suggest that while there was an increase in methadone-involved overdose deaths following the expanded provision of take-home methadone, the modest increase was associated with the spike in overall drug overdoses driven by illicitly made fentanyl in the early months of the COVID-19 pandemic.

In March of 2020, during which in the first half of the month take-home methadone was not available, overdose deaths both with and without methadone increased. After March of 2020, when the take-home methadone became available, overdose deaths not involving methadone continued to increase by approximately 69 deaths each month, whereas methadone-involved overdoses remained stable.

National Institute on Drug Abuse Director and senior author of the study Nora Volkow, MD, was quoted in a National Institutes of Health (NIH) news release saying, "Treatment is an essential tool to stop the addiction and overdose crises, but it is vastly underused . . . This evidence adds significant weight to the argument that effective treatment for substance use disorders should be offered in an accessible and practical way that works for people who need it."

Click here to access the research letter and click here to access the NIH news release for more information.

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